Probes for Bacterial Infections
We are involved in the design and synthesis of novel inhibitors of enzymes belonging the sulfur assimiliation pathway in bacteria. This project is developed in the frame of the INTEGRATE Marie Sklodowska-Curie ETN program, coordinated by University of Parma.
For further information feel free to contact Gabriele Costantino or Marco Pieroni
Recent publications:
- Campanini, B., Pieroni, M., Raboni, S., Bettati, S., Benoni, R., Pecchini, C., Constantino G., Mozzarelli, A., Sulfur assimilation pathway as a source of antibiotic targets. (2015) Current Med. Chem., 22 (2), 187-213 DOI: 10.2174/0929867321666141112122553
- Pieroni, M., Wan, B., Cho, S., Franzblau, S.G., Costantino, G.
Design, synthesis and investigation on the structure-activity relationships of N-substituted 2-aminothiazole derivatives as antitubercular agents
2014) European Journal of Medicinal Chemistry, 72, pp. 26-34.
DOI: 10.1016/j.ejmech.2013.11.007 - Bruno, A., Amori, L., Costantino, G. Computational insights into the mechanism of inhibition of OASS-A by a small molecule inhibitor (2013) Molecular Informatics, 32 (5-6), pp. 447-457. DOI: 10.1002/minf.201200174
- Amori, L., Katkevica, S., Bruno, A., Campanini, B., Felici, P., Mozzarelli, A., Costantino, G. Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase (2012) MedChemComm, 3 (9), pp. 1111-1116. DOI: 10.1039/c2md20100c
