Members Gabriele Costantino
Gabriele Costantino graduated in Chemistry at University of Perugia (Italy) in 1992. In 1994 he was appointed as research assistant at the Dipartimento di Chimica e Tecnologia del Farmaco of the University of Perugia. In 1998 Gabriele became associate professor of medicinal chemistry at the same Institution. Since January 2007 he is full professor of Medicinal Chemistry at University of Parma.
During his career, Gabriele has been visiting scientist at Searle R&D (Skokie, IL, USA) and at the Departmento de Quimica Organica of University of Barcelona (Spain). Gabriele has been visiting professor at the Institute of Organic Chemistry of Goethe University of Frankfurt AM (Germany)
Gabriele has been awarded in 2003 with the Farmaindustria/SCI prize as best young researcher in medicinal chemistry, and with the XVI Friederich Merz Fellowship for his research on molecular modeling of glutamate receptors.
His research interests cover the design and synthesis of potential neuroprotective agents, with special emphasis on those acting at metabotropic glutamate receptors and at the kynurenine pathway of tryptophan degradation, and of antibacterial agents. The other Gabriele’s main interest is the application of molecular dynamics to the study of the mechanism of activation of GPCR and nuclear receptors.
Author of more than 110 scientific papers, Gabriele has been coordinator of the PhD program in medicinal chemistry at University of Parma from 2007 to 2011.
Gabriele is member of the Executive Committee of the EFMC, Editor of MedChemWatch, the official newsletter of the European Federation for Medicinal Chemistry, and vice-President of the Division of Medicinal Chemistry of the Italian Chemical Society.
Selected publications:
- Capelli, A.M., Costantino, G., Unbinding pathways of VEGFR2 inhibitors revealed by steered molecular dynamics (2014) Journal of Chemical Information and Modeling, 54 (11), pp. 3124-3136. DOI: 10.1002/minf.201000162
- Vallerini, G.P., Amori, L., Beato, C., Tararina, M., Wang, X.-D., Schwarcz, R., Costantino, G. 2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: A step toward new antiexcitotoxic agents (2013) Journal of Medicinal Chemistry, 56 (23), pp. 9482-9495. DOI: 10.1021/jm401249c
- Capelli, A.M., Bruno, A., Entrena Guadix, A., Costantino, G. Unbinding pathways from the glucocorticoid receptor shed light on the reduced sensitivity of glucocorticoid ligands to a naturally occurring, clinically relevant mutant receptor (2013) Journal of Medicinal Chemistry , 56 (17), pp. 7003-7014. DOI: 10.1021/jm400802b
- Beato, C., Beccari, A.R., Cavazzoni, C., Lorenzi, S., Costantino, G. Use of experimental design to optimize docking performance: The case of LiGenDock, the docking module of ligen, a new de novo design program (2013) Journal of Chemical Information and Modeling, 53 (6), pp. 1503-1517. DOI: 10.1021/ci400079k
- Beccari, A.R., Cavazzoni, C., Beato, C., Costantino, G. LiGen: A high performance workflow for chemistry driven de novo design (2013) Journal of Chemical Information and Modeling, 53 (6), pp. 1518-1527. DOI: 10.1021/ci400078g
- Bruno, A., Costantino, G., de Fabritiis, G., Pastor, M., Selent, J. Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCR (2012) PLoS ONE, 7 (8), art. no. e42023, . DOI: 10.1371/journal.pone.0042023
- Pellicciari, R., Camaioni, E., Gilbert, A.M., Macchiarulo, A., Bikker, J.A., Shah, F., Bard, J., Costantino, G., Gioiello, A., Robertson, G.M., Sabbatini, P., Venturoni, F., Liscio, P., Carotti, A., Bellocchi, D., Cozzi, A., Wood, A., Gonzales, C., Zaleska, M.M., Ellingboe, J.W., Moroni, F. Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ (2011) MedChemComm, 2 (6), pp. 559-565. DOI: 10.1039/c1md00021g
- Pellicciari, R., Costantino, G., Fiorucci, S., Farnesoid X receptor: From structure to potential clinical applications (2005) Journal of Medicinal Chemistry, 48 (17), pp. 5383-5403 DOI: 10.1021/jm0582221
- Pellicciari, R., Fiorucci, S., Camaioni, E., Parks, D.J., Willson, T.M., 6α-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity (2002) Journal of Medicinal Chemistry, 45 (17), pp. 3569-3572 DOI: 10.1021/jm025529g
