Members Marco Pieroni

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Marco Pieroni graduated in 2003 in Pharmacy with a thesis regarding the synthesis of novel quinolones for the treatment of resistant bacterial strains. Right after his degree, he joined the medicinal chemistry group of Prof Fravolini and Prof Cecchetti in Perugia as a PhD student, continuing his work on the research of novel quinolone-like scaffolds and novel therapeutic approaches for the treatment of resistant infections. After his PhD thesis defence, in 2007, he shortly remained in the group of Prof Cecchetti before leaving to Chicago, at the UIC College of Pharmacy, where he spent 3 years as research assistant, first, and research assistant professor and drug metabolism lecturer, later, in the group of Prof Alan P. Kozikowski. In 2011 he was hired as research assistant professor at the University of Hawai’i at Hilo, collaborating with professor Ghee Tan in the synthesis of derivatives of natural compounds for the treatment of parasitic diseases. At the end of 2011 he joined the group of Prof Costantino, where he currently is a research assistant. Marco’s research is mostly focused on medicinal chemistry for the treatment of bacterial and parasitic infections, with particular emphasis on the treatment of susceptible and resistant M. tuberculosis. Recently, he has focused his attention on other therapeutic areas, such as CNS diseases and immunology.

Selected publications:

• Campanini, B., Pieroni, M., Raboni, S., Bettati, S., Benoni, R., Pecchini, C., Constantino G., Mozzarelli, A., Sulfur assimilation pathway as a source of antibiotic targets. (2015) Current Med. Chem., 22 (2), 187-213 DOI: 10.2174/0929867321666141112122553
• Viveiros, M., Pieroni, M., Spectinamides: a challenge, a proof, and a suggestion. (2014) Trends in Microbiol. , 22, 170-171 DOI: 10.1016/j.tim.2014.02.008
• Lun S, Guo H, Onajole OK, Pieroni M, Gunosewoyo H, Chen G, Tipparaju SK, Ammerman NC, Kozikowski AP, Bishai WR. Indoleamides are active against drug-resistant Mycobacterium tuberculosis. (2013) Nat Commun. Dec 19;4:2907. DOI: 10.1038/ncomms3907
• Onajole, O.K.; Pieroni, M.; Tipparaju, S. K.; Lun, S.; Stec, J.; Chen, G.; Gunosewoyo, H.; Guo, H.; Ammerman, N.C.; Bishai, W.R.; Kozikowski, A.P. Preliminary Structure-Activity Relationships and Biological Evaluation of Novel Antituberculat Indolecarboxyamide Derivatives Against Drug-Susceptible and Drug-Resistant Mycobacterium Tuberculosis Strains. (2013) J. Med. Chem., 56(10), 4093-4103
  DOI: 10.1021/jm4003878