The identification of chemical probes able to modulate protein functions and their optimization into high-content leads are key activities of P4T.
Two different approaches are regularly used to develop novel chemical probes:
The computational approaches we use to guide the synthesis of tailored chemical probes are:
Highly functionalized chemical probes are generated via combinatorial approaches. We develop atom- and cost-efficient multicomponent strategies that, coupled with microwave-assisted techniques, allow to quickly generate new chemical probes for drug discovery purposes.
Different synthetic techniques are regularly used to produce chemical diversity around targeted, privileged and natural scaffolds: solid-phase synthesis, parallel synthesis, microwave-assisted synthesis, click-chemistry, and multicomponent reactions.
These combinatorial methodologies are also used as an input to design large virtual libraries of synthetically-accessible compounds for virtual screening and hit-optimization campaign.